Nedoroslev graduated from Altai State University with a degree in physics in 1985. In 1989 graduated from Moscow Institute of Electronic Technology with a postgraduate degree in «The technology of manufacturing of semiconductors and devices on their basis». Ph.D. in Economics.
In business since 1987. He is the founder of the «Kaskol» group and the Machine Tool company «STAN». Member of The Government Expert Council.
Nedoroslev is the co-chairman and member of presidium of the General Council of All-Russia Public Organization Business Russia and a member of the board of All-Russia Industrial Employers Association Russian Engineering Union.
Sergey Nedoroslev is a member of the Boards of Directors of OJSC Russian Railways, JSC Engineering Center ECAR and a member of Supervisory Board of OJSC United Rocket and Space Corporation.