One of the preconditions for a dynamic development of an economy is an effective collaboration in manufacturing between major, systemically important companies and SMEs, which often are international. The former place orders and provide demand, research funding and market access, while the latter are able to respond quickly to changes, are flexible and deliver higher quality. This is particularly important for sectors where innovation is at the core of success. Economic growth and value creation demand that harmonious relations exist between these two segments of the economy yet this cannot always be achieved. Italy and other European countries have some of the best experiences in this respect. The heads of major technology companies of Italy and Russia and their partners among SMEs will discuss the possible forms of collaboration between big and small businesses, as well as explore and existing challenges and prospects.