The Strategy for Spatial Development, which aims to improve the effectiveness of state support measures, identifies promising economic specializations for all constituent entities of the Russian Federation based on their competitive advantages. Smart specialization may be one of the tools for landing effective specializations and enhancing the innovative activity of regions. What approach is used in Russia to provide state support for sectors of the economy? What methodology is used to select priorities for smart specialization and adapt it in Russia? What management system, mechanisms, tools and implementation procedures are needed at the federal level to implement smart specialization? Who should play the leading role in defining smart specializations the state, regions or business? How should territorial support instruments correlate to the requirements of international organizations?