The Eurasian Economic Commission the regulatory body of the Eurasian Economic Union and the Association of Southeast Asian Nations signed a Memorandum on Economic Cooperation during the ASEAN summit in November 2018. The two integration associations have demonstrated a strong desire to deepen and expand trade, economic, and investment cooperation. Today, various mechanisms exist for interaction between the EAEU and ASEAN ranging from a free trade zone (Vietnam) to the Memorandum of Cooperation (Singapore, Cambodia, and Thailand). Business communities and key business associations have become actively involved in the dialogue. What opportunities and advantages does the EAEU offer for businesses and attracting foreign partners and investments, and how can ASEAN countries take advantage of this? Which sectors are the EAEU and ASEAN trading in today, and which sectors have the best prospects for the further development of trade? What are the main problems and challenges of developing trade and business collaboration between EAEU and ASEAN members?