Open borders and an increasing resource mobility in the modern world make the economic policy-driven analysis ever more global. The bottom-up analysis can help solve many economic puzzles and grasp nascent trends that later capture the whole system. Outcomes of regional analysis are used in decision-making in the Bank of Russia and many central banks both in large and relatively small economies. Which questions can regional analysis answer? Determining and delivering on the monetary policy target is it sufficient to track country-average inflation or should its distribution by region, border indicators and price divergence risks be taken into account? What are the main determinants of the inflation diversity? Such information is helpful in decision-making on monetary policy, macroprudential and public policy as a whole.