The inevitability of unabated globalization and its unquestioned benefit for the global community have recently unravelled, straining national politics, altering international relations, and transforming global markets. In its place are emerging regional trading blocks, such as TPP and TTIP, to name a few, a new generation of financial and economic institutions, and the potential for new trade and investment flows. But the many risks of destabilization and a growing tide of geopolitical turmoil are challenging policymakers and businesses to navigate this transformation to a new global paradigm. How will these new factors impact issues that, by their nature, are global, such as energy, climate change, trade, finance, etc.? And what steps should be taken to mitigate risks and create a more sustainable economic architecture?